XIAP and Ki-67: A Correlation Between Antiapoptotic and Proliferative Marker Expression in Benign and Malignant Tumours of Salivary Gland: An Immunohistochemical Study
Published: February 1, 2015 | DOI: https://doi.org/10.7860/JCDR/2015/.5604
Bhupesh Bhayyaji Bagulkar, Madhuri Gawande, Minal Chaudhary, Amol Ramchandra Gadbail, Swati Patil, Smita Bagulkar
1. Assistant Professor, Department of Oral and Maxillofacial Pathology and Microbiology, Sri Aurobindo College of Dentistry, Indore , Madhya Pradesh, India.
2. Professor, Department of Oral and Maxillofacial Pathology & Microbiology, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences,
Sawangi (M), Wardha, Maharashtra, India.
3. Professor and Head, Department of Oral and Maxillofacial Pathology & Microbiology, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical
Sciences, Sawangi (M), Wardha, Maharashtra, India.
4. Associate Professor, Department of Oral and Maxillofacial Pathology & Microbiology, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical
Sciences, Sawangi (M), Wardha, Maharashtra, India.
5. Professor, Department of Oral and Maxillofacial Pathology & Microbiology, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences,
Sawangi (M), Wardha, Maharashtra, India.
6. Lecturer
Correspondence
Dr. Bhupesh Bhayyaji Bagulkar,
Assistant Professor, Department of Oral and Maxillofacial Pathology, Sri Aurobindo College of Dentistry,
Indore-Ujjain state Highway, Bhanwrasala, Tehsil- Sanwer, District- Indore, 453111, Madhya Pradesh, India.
E-mail: bb_9823@yahoo.co.in
Background: Impaired balance between cell proliferation and apoptosis is crucial to the development of malignant neoplasm. The purpose of this study was to evaluate and compare the expression of X-Linked inhibitor of apoptotic protein (XIAP) (antiapoptotic marker) and Ki-67 (proliferative marker) expression in benign and malignant salivary gland (SG) tumours.
Materials and Methods: The study consisted of 40 cases of benign SG tumours and 50 cases of malignant SG tumours. The immunohistochemistry was carried out by using Ki-67 antibody (clone MIB-1) and XIAP antibody in all the groups.
Results: XIAP expression was significantly higher in malignant SG tumours than benign SG tumours (p = 0.016). Ki-67 LI was significantly higher in malignant SG tumours than benign SG tumours (p = 0.0002). Statistically significant positive correlation between Ki-67 count and XIAP expression was noted in benign and malignant SG tumours (p = 0.000).
Conclusion: As the expression of an antiapoptotic marker (XIAP) increases, the expression of a proliferative marker (Ki-67) also increases from benign to malignant SG tumours. Thus, targeted therapy of XIAP may play a future role in the management of SG malignancy.
[
FULL TEXT ] | [ PDF]